Effect of bilirubin and Gilbert syndrome on health: cohort analysis of observational, genetic, and Mendelian randomisation associations.
Fergus W HamiltonKwm AbeysekeraWilliam T HamiltonNicholas J TimpsonPublished in: BMJ medicine (2023)
Only 3% of participants who are homozygous for rs887829-T have a recorded diagnosis of Gilbert syndrome. Carriers of this genotype have modest increases in the odds of developing biliary pathology and pityriasis rosea. Evidence from the analyses of genetic data suggests that bilirubin has no likely causal role in protection from cardiovascular disease, chronic obstructive pulmonary disease, or other key healthcare outcomes and therefore represents a poor target for therapeutic intervention for these outcomes.
Keyphrases
- healthcare
- chronic obstructive pulmonary disease
- cardiovascular disease
- genome wide
- randomized controlled trial
- public health
- case report
- type diabetes
- mental health
- copy number
- electronic health record
- health information
- gene expression
- coronary artery disease
- machine learning
- deep learning
- climate change
- human health
- health promotion