Epigenetic events involved in organic cation transporter 1-dependent impaired response of hepatocellular carcinoma to sorafenib.
Ruba Al-AbdullaElisa LozanoRocio I R MaciasMaria J MonteOscar BrizColm J O'RourkeMaria A SerranoJesus M BanalesMatias A AvilaMaria L Martinez-ChantarAndreas GeierJesper B AndersenJose J G MarinPublished in: British journal of pharmacology (2019)
Impaired hOCT1 expression/function in HCC, in part due to epigenetic modifications, plays an important role in the poor pharmacological response of this cancer to sorafenib.