Short chain fatty acids stimulate insulin secretion and reduce apoptosis in mouse and human islets in vitro: Role of free fatty acid receptor 2.

Attilio PingitoreNoemi Gonzalez-AbuinInmaculada Ruz-MaldonadoGuo C HuangGary FrostShanta Jean Persaud

Published in: Diabetes, obesity & metabolism (2018)

Our results indicate that FFAR2 directly mediates both the stimulatory effects of SA and SP on insulin secretion and their protection against islet apoptosis. We have also shown that SCFA coupling in islets occurs via Gq-coupled intracellular signalling.

Keyphrases

fatty acid
endoplasmic reticulum stress
cell cycle arrest
oxidative stress
cell death
endothelial cells
induced pluripotent stem cells
room temperature
pi k akt