A Small Molecule Agonist of Krüppel-Like Factor 15 in Proteinuric Kidney Disease.

Yiqing GuoNehaben A GujaratiAndrew K Chow Brock T BoysanRobert BronsteinJohn Cijiang HeMonica P ReveloNavjot Singh PablaRobert C RizzoBhaskar Das Sandeep K Mallipattu

Published in: Journal of the American Society of Nephrology : JASN (2024)

By developing and validating a cell-based high-throughput screen in human podocytes, we identified a novel agonist for KLF15 with salutary effects in proteinuric murine models through direct inhibition of IKKβ kinase activity.

Keyphrases

high throughput
small molecule
single cell
endothelial cells
induced pluripotent stem cells
cell therapy
high glucose
pluripotent stem cells
protein protein
transcription factor
tyrosine kinase
stem cells
protein kinase