Alcohol Use Disorder-Associated DNA Methylation in the Nucleus Accumbens and Dorsolateral Prefrontal Cortex.
Julie D WhiteMelyssa S MintoCaryn WillisBryan C QuachShizhong HanRan TaoAmy Deep-SoboslayLea ZillichShaunna L ClarkEdwin J C G van den OordThomas M HydeR Dayne MayfieldBradley Todd WebbEric O JohnsonJoel E KleinmanLaura J BierutDana B HancockPublished in: medRxiv : the preprint server for health sciences (2024)
Our findings identify AUD-associated methylation signals, the majority of which are specific within NAc or DLPFC. Some signals may constitute predisposing genetic and epigenetic variation, though more work is needed to further disentangle the neurobiological gene regulatory differences associated with AUD.