Visible-light-promoted radical cross-coupling of para-quinone methides with N-substituted anilines: an efficient approach to 2,2-diarylethylamines.

Qiao-Lei WuJing GuoGong-Bin HuangAlbert S C ChanJiang Weng Gui Lu

Published in: Organic & biomolecular chemistry (2020)

An efficient protocol to access 2,2-diarylethylamines via visible-light-promoted radical reactions of para-quinone methides (p-QMs) with N-alkyl anilines has been disclosed. These reactions feature metal-free, redox-neutral, and mild reaction conditions with wide functional group compatibility.

Keyphrases

visible light
machine learning
randomized controlled trial
molecular docking
electron transfer