Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial.

Edward S ChambersClaire S ByrneDouglas J MorrisonKevin G MurphyTom PrestonCatriona TedfordIsabel Garcia-PerezSofia FountanaJose Ivan Serrano-ContrerasElaine HolmesCatherine J ReynoldsJordie F RobertsRosemary J BoytonDaniel M AltmannJulie Anne Kathryn McDonaldJulian R MarchesiArne N AkbarNatalie E RiddellGareth A WallisGary S Frost

Published in: Gut (2019)

These data demonstrate a distinctive physiological impact of raising colonic propionate delivery in humans, as improvements in insulin sensitivity promoted by IPE and inulin were accompanied with different effects on the plasma metabolome, gut bacterial populations and markers of systemic inflammation.

Keyphrases

clinical trial
study protocol
open label
phase iii
phase ii
randomized controlled trial
big data
machine learning
placebo controlled