Results and Molecular Correlates from a Pilot Study of Neoadjuvant Induction FOLFIRINOX Followed by Chemoradiation and Surgery for Gastroesophageal Adenocarcinomas.
Jennifer Y WoJeffrey W ClarkChristine E EylerMari A Mino-KenudsonSamuel J KlempnerJill N AllenFlorence K KeaneAparna R ParikhEric J RoelandLorraine C DrapekDavid P RyanRyan B CorcoranEmily Van SeventerIsobel J FetterHeather A ShahzadeMelin J KhandekarMichael LanutiChristopher R MorseRebecca S HeistChristine A UlysseBenjamin ChristopherChristian BagliniBeow Y YeapJohn T MullenTheodore S HongPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Here we show neoadjuvant FOLFIRINOX followed by chemoradiation for locally advanced gastroesophageal cancer is feasible and yields a high rate of pCR. ctDNA appears to be a promising predictor of postoperative recurrence.See related commentary by Catenacci, p. 6281.
Keyphrases
- locally advanced
- rectal cancer
- squamous cell
- squamous cell carcinoma
- radiation therapy
- papillary thyroid
- minimally invasive
- coronary artery bypass
- patients undergoing
- lymph node metastasis
- surgical site infection
- single molecule
- circulating tumor
- free survival
- percutaneous coronary intervention
- acute coronary syndrome