Integrated analysis of gene modulation profile identifies pathogenic factors and pathways in the liver of diabetic mice.
Thai Quoc TranYuan-Man HsuYu-Chuen HuangChao-Jung ChenWei-De LinYing-Ju LinWen-Ling LiaoWei-Yong LinJai-Sing YangJinn-Chyuan SheuShih-Yin ChenFuu-Jen TsaiPublished in: Journal of diabetes and metabolic disorders (2019)
These findings provide valuable reference data that can facilitate further detailed investigations to elucidate the pathogenic mechanism of obesity-induced diabetes in mice, which can be associated with the human condition to inform new prevention and treatment strategies.
Keyphrases
- high fat diet induced
- type diabetes
- endothelial cells
- genome wide
- high glucose
- insulin resistance
- metabolic syndrome
- cardiovascular disease
- weight loss
- diabetic rats
- copy number
- electronic health record
- induced pluripotent stem cells
- glycemic control
- big data
- pluripotent stem cells
- weight gain
- dna methylation
- drug induced
- machine learning
- oxidative stress
- adipose tissue
- wild type