Cervical cancer is the second most common gynecological malignancy globally; it seriously endangers women's health because of its high morbidity and mortality. Conventional treatments are prone to drug resistance, recurrence and metastasis. Therefore, there is an urgent need to develop new drugs with high efficacy and low side effects to prevent and treat cervical cancer. In recent years, plant-derived natural products have been evaluated as potential anticancer drugs that preferentially kill tumor cells without severe adverse effects. A growing number of studies have shown that natural products can achieve practical anti-cervical-cancer effects through multiple mechanisms, including inhibition of tumor-cell proliferation, induction of apoptosis, suppression of angiogenesis and telomerase activity, enhancement of immunity and reversal of multidrug resistance. This paper reviews the therapeutic effects and mechanisms of plant-derived natural products on cervical cancer and provides references for developing anti-cervical-cancer drugs with high efficacy and low side effects.
Keyphrases
- cell proliferation
- healthcare
- public health
- oxidative stress
- mental health
- endothelial cells
- systematic review
- randomized controlled trial
- risk assessment
- type diabetes
- endoplasmic reticulum stress
- polycystic ovary syndrome
- human health
- insulin resistance
- pregnant women
- cell cycle
- adipose tissue
- cell wall
- signaling pathway
- cell cycle arrest
- social media
- pregnancy outcomes
- combination therapy
- wound healing
- meta analyses
- breast cancer risk