LPAR5 confers radioresistance to cancer cells associated with EMT activation via the ERK/Snail pathway.
Xiao-Ya SunHao-Zheng LiDa-Fei XieShan-Shan GaoXin HuangHua GuanChen-Jun BaiPing-Kun ZhouPublished in: Journal of translational medicine (2022)
LPAR5 is an important upstream regulator of IR-induced EMT that modulates the ERK/Snail pathway. This study provides further insights into understanding the mechanism of radiation-induced EMT and identifies promising targets for improving the effectiveness of cancer radiation therapy.
Keyphrases
- epithelial mesenchymal transition
- radiation induced
- signaling pathway
- radiation therapy
- pi k akt
- cell proliferation
- randomized controlled trial
- systematic review
- papillary thyroid
- high glucose
- genome wide
- diabetic rats
- transcription factor
- squamous cell
- locally advanced
- endothelial cells
- drug induced
- dna damage
- young adults
- rectal cancer