Osteoarthritis accounts for 0.6% of disability-adjusted life years globally. There is a paucity of research focused on cannabis-based medicinal products (CBMPs) for osteoarthritic chronic pain management. This study aims to assess changes in validated patient-reported outcome measures (PROMs) and CBMP clinical safety in patients with osteoarthritis. A prospective case series from the UK Medical Cannabis Registry was analyzed. Primary outcomes were changes in the Brief Pain Inventory (BPI), McGill Pain Questionnaire (MPQ2), EQ-5D-5L, Generalized Anxiety Disorder-7 (GAD-7) questionnaire, and Single-Item Sleep Quality Scale (SQS) at 1-, 3-, 6-, and 12-month follow-ups from baseline. Common Terminology Criteria for Adverse Events v.4.0 was used for adverse event (AE) analysis. Statistical significance was defined as p < 0.050. Seventy-seven patients met inclusion criteria. CBMP initiation correlated with BPI pain severity ( p = 0.004), pain interference ( p = 0.005), and MPQ2 ( p = 0.017) improvements at all follow-ups compared to baseline. There were improvements in the EQ-5D-5L index ( p = 0.026), SQS ( p < 0.001), and GAD-7 ( p = 0.038) up to 6 and 3 months, respectively. Seventeen participants (22.08%) recorded 76 mild AEs (34.86%), 104 moderate AEs (47.71%), and 38 severe AEs (17.43%). Though causality cannot be assumed in this observational study, results support development of randomized control trials for osteoarthritis pain management with CBMPs.
Keyphrases
- pain management
- chronic pain
- patient reported
- sleep quality
- rheumatoid arthritis
- healthcare
- psychometric properties
- patient reported outcomes
- knee osteoarthritis
- cross sectional
- end stage renal disease
- ejection fraction
- multiple sclerosis
- chronic kidney disease
- newly diagnosed
- depressive symptoms
- emergency department
- neuropathic pain
- open label
- clinical trial
- type diabetes
- physical activity
- tyrosine kinase
- high intensity
- double blind
- insulin resistance
- drug induced
- adipose tissue
- early onset
- placebo controlled
- phase ii
- skeletal muscle
- weight loss