Spatial distribution of elvitegravir and tenofovir in rat brain tissue: Application of matrix-assisted laser desorption/ionization mass spectrometry imaging and liquid chromatography/tandem mass spectrometry.
Sphamandla NtshangaseSipho MdandaTricia NaickerHendrik Gerhardus KrugerSooraj BajinathThavendran GovenderPublished in: Rapid communications in mass spectrometry : RCM (2020)
LC/MS/MS and MALDI-MSI provided valuable information about the relative concentration and the spatial distribution of the two common antiretroviral drugs. This study has also shown the capability of MALDI-MSI for direct visualization of pharmaceutical drugs in situ.
Keyphrases
- mass spectrometry
- liquid chromatography tandem mass spectrometry
- liquid chromatography
- high resolution
- simultaneous determination
- solid phase extraction
- high performance liquid chromatography
- gas chromatography
- capillary electrophoresis
- ms ms
- human immunodeficiency virus
- hiv infected
- tandem mass spectrometry
- hiv positive
- healthcare
- hiv aids
- hepatitis c virus
- drug induced
- health information
- men who have sex with men