Effect of prucalopride on sildenafil-induced inhibition of esophageal peristalsis in healthy adults.
Ming-Wun WongTso-Tsai LiuChih-Hsun YiJui-Sheng HungWei-Yi LeiShu-Wei LiangWilliam C OrrChien-Lin ChenPublished in: Journal of gastroenterology and hepatology (2020)
Prucalopride modulates sildenafil-induced inhibition of primary peristalsis by increasing its effectiveness and peristaltic wave amplitude. Our findings suggest that activation of 5-hydroxytryptamine 4 receptors plays a role in mediating sildenafil-induced inhibition of esophageal primary peristalsis rather than secondary peristalsis.