Inhibition of inflammation and apoptosis through the cyclic GMP-AMP synthase-stimulator of interferon genes pathway by stress granules after ALKBH5 demethylase activation during diabetic myocardial ischaemia-reperfusion injury.
Wenyuan LiRenwu QinZhen TangChangqing WangHeng XuWei LiYan LengYao WangZhong-Yuan XiaPublished in: Diabetes, obesity & metabolism (2024)
Both ALKBH5 and SGs inhibited myocardial inflammation and apoptosis during diabetic myocardial ischaemia-reperfusion. Mechanistically, ALKBH5 might inhibit the apoptosis of cardiomyocytes by promoting the expression of SGs through the cGAS-STING pathway.
Keyphrases
- oxidative stress
- endoplasmic reticulum stress
- cell cycle arrest
- left ventricular
- cell death
- acute myocardial infarction
- type diabetes
- cerebral ischemia
- poor prognosis
- wound healing
- acute ischemic stroke
- genome wide
- dendritic cells
- pi k akt
- escherichia coli
- endothelial cells
- cystic fibrosis
- stress induced
- atrial fibrillation