Impact of scaling up dolutegravir on antiretroviral resistance in South Africa: A modeling study.
Anthony HauserKatharina KusejkoLeigh F JohnsonHuldrych F GunthardJulien RiouGilles WandelerMatthias EggerRoger D KouyosPublished in: PLoS medicine (2020)
Our model shows the potential benefit of scaling up DTG-based regimens for halting the rise of NNRTI resistance. Starting or switching all men and women to DTG would lead to a sustained decline in resistance levels, whereas using DTG-based ART in all men, or in men and women beyond childbearing age, would only slow down the increase in levels of NNRTI PDR.