Contribution of common and rare genetic variants in CEP72 on vincristine-induced peripheral neuropathy in brain tumour patients.
Marije J KlumpersAnnouk C A M BrandMarina HakobjanGiovanna GattusoElisabetta SchiavelloMonica TerenzianiMaura MassiminoCorrie E M GiddingHenk-Jan GuchelaarD Maroeska W M Te LooMarieke J H CoenenPublished in: British journal of clinical pharmacology (2022)
The association of CEP72 rs924607 in vincristine-induced neuropathy was not confirmed in a cohort of brain tumour patients, but did contribute to its suggested effect when combined in a cross-disease meta-analysis. The importance of other genetic variations in CEP72 on vincristine-induced neuropathy was demonstrated. This study contributes to evidence of the importance of genetic variants in CEP72 in development of vincristine-induced toxicity, and provides guidance for future prospective studies.
Keyphrases
- end stage renal disease
- high glucose
- diabetic rats
- systematic review
- newly diagnosed
- ejection fraction
- chronic kidney disease
- prognostic factors
- drug induced
- peritoneal dialysis
- oxidative stress
- randomized controlled trial
- endothelial cells
- white matter
- gene expression
- patient reported outcomes
- resting state
- dna methylation
- patient reported