A Porous Bimetallic Au@Pt Core-Shell Oxygen Generator to Enhance Hypoxia-Dampened Tumor Chemotherapy Synergized with NIR-II Photothermal Therapy.
Jingyu SunJinping WangWei HuYuhao WangQiang ZhangXiaotong HuTsengming ChouBeilu ZhangCosmo GallaroMeghan HalloranLyu LiangLei RenHongjun WangPublished in: ACS nano (2022)
The characteristic hypoxia of solid tumors and inadequate oxygen supply become a key causation of the resistance to chemotherapy in cancer treatment. Herein, a bimetallic oxygen nanogenerator, i . e ., porous Au@Pt core-shell nanostructures, is particularly developed to reduce the multidrug resistance by oxygenating the tumor along with synergistic chemo-photothermal therapy for efficient tumor eradication. The porous platinum (Pt) shell was able to catalyze oxygen generation from endogenous hydrogen peroxide in the tumor, reducing the exocytosis of doxorubicin (DOX) via suppressed expression of hypoxia-inducible factor-1α, multidrug resistance gene 1, and P-glycoprotein. The strong absorbance of Au@Pt nanostructures in NIR window II enabled NIR-II photothermal therapy. Further incorporation of DOX into the mesopores of Au@Pt nanostructures with the assistance of phase change materials (PCM) led to the formulation of Au@Pt-DOX-PCM-PEG nanotherapeutics for NIR-II-activated chemotherapy. This work presents an efficient H 2 O 2 -driven oxygenerator for enhanced hypoxia-dampened chemotherapy and NIR-II photothermal therapy.
Keyphrases
- photodynamic therapy
- drug release
- hydrogen peroxide
- sensitive detection
- drug delivery
- locally advanced
- fluorescence imaging
- reduced graphene oxide
- fluorescent probe
- cancer therapy
- metal organic framework
- endothelial cells
- poor prognosis
- squamous cell carcinoma
- genome wide
- dna methylation
- helicobacter pylori infection
- transcription factor
- copy number
- helicobacter pylori
- gene expression
- binding protein