Net benefit in the presence of correlated prioritized outcomes using generalized pairwise comparisons: A simulation study.
Joris GiaiDelphine Maucort-BoulchBrice OzenneJean-Christophe ChiêmMarc BuyseJulien PéronPublished in: Statistics in medicine (2020)
Correlations between outcomes analyzed with GPC led to substantial but predictable modifications of Δ and its estimate. Correlations should be taken into consideration when performing sample size estimations in clinical trials.