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Net benefit in the presence of correlated prioritized outcomes using generalized pairwise comparisons: A simulation study.

Joris GiaiDelphine Maucort-BoulchBrice OzenneJean-Christophe ChiêmMarc BuyseJulien Péron
Published in: Statistics in medicine (2020)
Correlations between outcomes analyzed with GPC led to substantial but predictable modifications of Δ and its estimate. Correlations should be taken into consideration when performing sample size estimations in clinical trials.
Keyphrases
  • clinical trial
  • randomized controlled trial
  • metabolic syndrome
  • skeletal muscle
  • insulin resistance