Role of Diuretics in Cardiovascular Events and Mortality in Systolic Blood Pressure Intervention Trial: A Post Hoc Analysis.
Shweta BansalRobert BoucherJincheng ShenGuo WeiGlenn M ChertowPaul K WheltonWilliam C CushmanAlfred K CheungSrinivasan Beddhunull nullPublished in: Clinical journal of the American Society of Nephrology : CJASN (2024)
The favorable effects of intensive systolic BP lowering on cardiovascular end points and all-cause mortality in SPRINT were independent of and not mediated by time-varying diuretics use. However, thiazide-type diuretics use associated with benefit if intensive systolic BP lowering was targeted.
Keyphrases
- blood pressure
- cardiovascular events
- coronary artery disease
- left ventricular
- hypertensive patients
- cardiovascular disease
- heart failure
- heart rate
- randomized controlled trial
- study protocol
- clinical trial
- phase iii
- blood glucose
- type diabetes
- high intensity
- adipose tissue
- phase ii
- metabolic syndrome
- resistance training
- risk factors
- insulin resistance
- weight loss
- drug delivery