A novel mouse model of calcific aortic valve stenosis.

Ningjing Qian Yaping Wang Wangxing Hu Naifang Cao Yi Qian Jinyong Chen Juan Fang Dilin Xu Haochang Hu Shuangshuang Yang Dao Zhou Hanyi Dai Dongdong Wei Wangxing Hu Xianbao Liu

Published in: Animal models and experimental medicine (2024)

We established a novel mouse model of CAVS that could be induced efficiently, robustly and economically, and without genetic intervention. It provides a fast track to explore the underlying mechanisms of CAVS and to identify more effective pharmacological targets.

Keyphrases

aortic valve
mouse model
transcatheter aortic valve replacement
transcatheter aortic valve implantation
aortic valve replacement
aortic stenosis
randomized controlled trial
high glucose
diabetic rats
genome wide
heart failure
drug induced
copy number
dna methylation
stress induced