Active Heme Metabolism Suppresses Macrophage Phagocytosis via the TLR4/Type I IFN Signaling/CD36 in Uterine Endometrial Cancer.

Xing ZhangYi-Xing YangJia-Jing LuDing-Yu HouAyitila AbudukeyoumuHong-Wei ZhangMing-Qing Li Feng Xie

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2024)

Collectively, these findings elucidate that active heme metabolism of UECCs directly decreases phagocytosis by controlling the secretion of TLR4-mediated IFN Iα and the expression of CD36, and further contributing to the immune escape of UEC.

Keyphrases

endometrial cancer
immune response
toll like receptor
inflammatory response
dendritic cells
poor prognosis
nk cells
adipose tissue
signaling pathway
nuclear factor
long non coding rna