A Challenging Diagnosis: Placental Mesenchymal Dysplasia-Literature Review and Case Report.
Claudia MehedintuFrancesca FrincuOana-Maria IonescuMonica Mihaela CirstoiuMaria SajinMaria OlincaElvira BratilaAida PetcaAndreea Carp-VeliscuPublished in: Diagnostics (Basel, Switzerland) (2022)
We describe a 22-year-old woman (2-gravid) case who was referred to our clinic at 18 weeks of gestation for a placenta with vesicular lesions discovered on prenatal examination routine. An ultrasound exam at 31 weeks of gestation showed numerous vesicular lesions, which gradually augmented as the pregnancy advanced. A live normal-appearing fetus was confirmed by intrauterine growth restriction (IUGR). The maternal serum β-human chorionic gonadotropin level remained in normal ranges. At some point, a multidisciplinary medical consensus considered the termination of the pregnancy, but the patient refused to comply. At 33 weeks of gestation, preterm premature rupture of membranes (pPROM) occurred, and she spontaneously delivered a 1600 g healthy female baby with a good long-term outcome. Placental mesenchymal dysplasia (PMD) was retrospectively diagnosed after confronting the data from ultrasound, chorionic villus sampling (CVS), amniocentesis, pathological examination, and immunohistochemical stain. The lack of sufficient reports of PMD determines doctors to be cautious and reserved, approaching these cases more radically than necessary. We reviewed this disease and searched for all cases of PMD associated with healthy, live newborns.
Keyphrases
- gestational age
- preterm birth
- case report
- birth weight
- low birth weight
- pregnancy outcomes
- magnetic resonance imaging
- bone marrow
- stem cells
- endothelial cells
- pregnant women
- healthcare
- primary care
- electronic health record
- ultrasound guided
- induced pluripotent stem cells
- big data
- quality improvement
- preterm infants
- pluripotent stem cells
- machine learning
- artificial intelligence
- computed tomography
- body mass index