Upregulation of nuclear factor E2-related factor 2 (Nrf2) represses the replication of herpes simplex virus type 1.

Li ZhangJiao WangZhan WangYing LiHui WangHongtu Liu

Published in: Virology journal (2022)

Our observations indicate that the Nrf2-ARE pathway activates a passive defensive response in the early stage of HSV-1 infection. Targeting the Nrf2 pathway demonstrates the potential for combating HSV-1 infection.

Keyphrases

herpes simplex virus
nuclear factor
oxidative stress
early stage
toll like receptor
poor prognosis
cancer therapy
immune response