Co-occurring hydrocephalus in autism spectrum disorder: a Danish population-based cohort study.
Tina Nørgaard MunchPaula Louise HedleyChristian Munch HagenMarie Bækvad-HansenJonas Bybjerg-GrauholmJakob GroveMerete NordentoftAnders Dupont BørglumPreben Bo MortensenThomas Mears WergeMads MelbyeDavid Michael HougaardMichael ChristiansenPublished in: Journal of neurodevelopmental disorders (2021)
Given the considerable risk of hydrocephalus among patients with autism spectrum disorder, we suggest that patients with autism spectrum disorder should be evaluated for co-occurring hydrocephalus on a routine basis as timely neurosurgical intervention is important. Likewise, attention must be paid to traits of autism spectrum disorder in children with hydrocephalus. The results of this study call for future investigations on a potential shared aetiology between hydrocephalus and autism spectrum disorder, including the role abnormal CSF dynamics in the pathogenesis of autism spectrum disorder.
Keyphrases
- autism spectrum disorder
- cerebrospinal fluid
- subarachnoid hemorrhage
- attention deficit hyperactivity disorder
- intellectual disability
- end stage renal disease
- brain injury
- randomized controlled trial
- ejection fraction
- newly diagnosed
- chronic kidney disease
- young adults
- prognostic factors
- working memory
- gene expression
- dna methylation
- clinical practice
- patient reported outcomes
- risk assessment
- patient reported