Researchers' experiences of the design and conduct challenges associated with parallel-group cluster-randomised trials and views on a novel open-cohort design.

Claire A Surr Laura MarsdenAlys GriffithsSharon CoxJane FosseyAdam MartinAndrew Toby Prevost Catherine Walshe Rebecca Walwyn

Published in: PloS one (2024)

Open-cohort CRT designs hold promise for addressing the challenges associated with standard CRT designs. Research is needed to provide clarity around definition and guidance on application.

Keyphrases

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cardiac resynchronization therapy
clinical trial
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mental health
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heart failure
randomized controlled trial
big data
finite element analysis
deep learning
artificial intelligence