Linking Cognitive Impairment with Amyloid-β Accumulation in Alzheimer's Disease: Insights from Behavioral Tests and FTIR Spectroscopy.

Heba Ahmed GaberEman Mohamed AlyEman Saad MohamedMarwa ElfolyMostafa Adel RabieMona Salah TalaatEl-Sayed Mahmoud El-Sayed

Published in: Journal of Alzheimer's disease reports (2023)

is a sensitive early biomarker in retina for AD. FTIR analysis of the retina revealed changes in hydrogen bond formation or destruction, alterations in lipid chain length and branching accompanied by depleted lipid content and carbonization, as well as degeneration of the retinal tissue due to AD.

Keyphrases

diabetic retinopathy
optic nerve
cognitive impairment
optical coherence tomography
fatty acid
high resolution
single cell
single molecule
cognitive decline
sewage sludge
solid state
mass spectrometry
transition metal