Intradermal lipopolysaccharide challenge as an acute in vivo inflammatory model in healthy volunteers.
Thomas P ButersPieter W HameetemanIris M E JansenFloris C van HindevoortWouter Ten VoordeEdwin FlorenciaMichelle OsseMarieke L de KamHendrika W GrievinkMascha SchoonakkerAmit A PatelSimon YonaDerek W GilroyErik LubbertsJeffrey DammanGary FeissRobert RissmannManon A A JansenJacobus BurggraafMatthijs MoerlandPublished in: British journal of clinical pharmacology (2021)
Intradermal LPS administration in humans causes an acute, localized and transient inflammatory reaction that is well-tolerated by healthy volunteers. This may be a valuable inflammation model for evaluating the pharmacological activity of anti-inflammatory investigational compounds in proof of pharmacology studies.