Human multipotent adult progenitor cell-conditioned medium improves wound healing through modulating inflammation and angiogenesis in mice.
Parinaz AhangarStuart J MillsLouise E SmithXanthe L StrudwickAnthony E TingBart VaesAllison J CowinPublished in: Stem cell research & therapy (2020)
These findings suggest that factors produced by MAPC cells can have an important effect on cutaneous wound healing by affecting skin cell proliferation and migration, balancing inflammation and improving the formation of extracellular matrix and angiogenesis. Development of stem cell-free therapy for the treatment of wounds may be a more clinically translatable approach for improving healing outcomes.
Keyphrases
- wound healing
- extracellular matrix
- cell free
- oxidative stress
- endothelial cells
- induced apoptosis
- single cell
- signaling pathway
- cell therapy
- circulating tumor
- induced pluripotent stem cells
- metabolic syndrome
- skeletal muscle
- vascular endothelial growth factor
- pluripotent stem cells
- young adults
- type diabetes
- endoplasmic reticulum stress
- bone marrow
- adipose tissue
- wild type