Sox17 Deficiency Promotes Pulmonary Arterial Hypertension via HGF/c-Met Signaling.
Chan Soon ParkSoo Hyun KimHae Young YangJu-Hee KimRalph Theo SchermulyYe Seul ChoHyejeong KangJae-Hyeong ParkEunhyeong LeeHyeonJin ParkJee Myung YangTae Wook NohSeung-Pyo LeeSun Sik BaeJinju HanYoung Seok JuJun Bean ParkInjune KimPublished in: Circulation research (2022)
The downregulation of Sox17 levels in pulmonary arterioles increases the susceptibility to PAH, particularly when exposed to hypoxia. Our findings suggest the reactive upregulation of HGF/c-Met signaling as a novel druggable target for PAH treatment.