Neonatal adverse stimulation might enhance the expression of spinal microglial Cat S, thereby activating the FKN/CX3CR1/p38 MAPK pathway and lead to visceral hypersensitivity in IBS-like rats. As a selective inhibitor of Cat S, LY3000328 could become a potential therapeutic option for IBS.
Keyphrases
- signaling pathway
- spinal cord
- irritable bowel syndrome
- insulin resistance
- drug induced
- poor prognosis
- neuropathic pain
- inflammatory response
- lipopolysaccharide induced
- pi k akt
- lps induced
- induced apoptosis
- binding protein
- epithelial mesenchymal transition
- spinal cord injury
- adipose tissue
- type diabetes
- metabolic syndrome
- skeletal muscle
- cell proliferation
- adverse drug
- long non coding rna
- oxidative stress