The AUstralian multidomain Approach to Reduce dementia Risk by prOtecting brain health With lifestyle intervention study (AU-ARROW): A study protocol for a single-blind, multi-site, randomized controlled trial.
Samantha L GardenerStephanie J FullerSharon L NaismithLaura BakerMiia KivipeltoVictor L VillemagneStuart M GrievePaul YatesStephanie R Rainey-SmithJuliana ChenBelinda ThompsonNicola J ArmstrongMalika G FernandoCarolina Blagojevic CastroSilochna MeghwarRema RamanAndrew GleasonCatriona IrelandRoger ClarnetteKaarin J AnsteyKevin TaddeiManohar GargHamid R SohrabiRalph N MartinsPublished in: Alzheimer's & dementia (New York, N. Y.) (2024)
Study protocol for a single-blind, randomized controlled trial, the AU-ARROW Study.The AU-ARROW Study is a member of the World-Wide FINGERS (WW-FINGERS) initiative.AU-ARROW's primary outcome measure is change in a global composite cognitive score.Extra significance from amyloid PET imaging, brain MRI, and retinal biomarker tests.Leading to development of an innovative treatment plan to reduce cognitive decline.
Keyphrases
- randomized controlled trial
- cognitive decline
- mild cognitive impairment
- pet imaging
- sensitive detection
- public health
- cardiovascular disease
- mental health
- metabolic syndrome
- magnetic resonance imaging
- computed tomography
- systematic review
- white matter
- risk assessment
- multiple sclerosis
- weight loss
- gold nanoparticles
- physical activity
- climate change
- quality improvement
- positron emission tomography
- combination therapy