Reporting quality of clinical trial protocols: a repeated cross-sectional study about the Adherence to SPIrit Recommendations in Switzerland, CAnada and GErmany (ASPIRE-SCAGE).
Dmitry GryaznovBelinda von NiederhäusernBenjamin SpeichBenjamin KasendaElena Ojeda-RuizAnette BlümleStefan SchandelmaierDominik MertzAyodele OdutayoYuki TomonagaAlain AmstutzChristiane Pauli-MagnusViktoria GloySzimonetta LohnerKarin BischoffKatharina WollmannLaura RehnerJoerg J MeerpohlAlain NordmannKatharina KlatteNilabh GhoshAla Taji HeraviJacqueline WongNgai ChowPatrick HongKimberly A McCord-De IacoSirintip SricharoenchaiJason Walter BusseArnav AgarwalRamon SaccilottoMatthias SchwenkglenksGiusi MoffaLars HemkensSally HopewellErik von ElmMatthias BrielPublished in: BMJ open (2022)
In 2012, industry-sponsored RCT protocols were reported more comprehensively than investigator-sponsored protocols. After publication of the SPIRIT checklist, investigator-sponsored protocols improved to the level of industry-sponsored protocols, which did not improve.