MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset.
Götz ThomallaClaus Z SimonsenFlorent BoutitieGrethe AndersenYves BerthezeneBastian ChengBharath CheripelliTae-Hee ChoFranz FazekasJens FiehlerIan FordIvana GalinovicSusanne GellissenAmir GolsariJohannes GregoriMatthias GüntherJorge GuibernauKarl Georg HäuslerMichael HennericiAndré KemmlingJacob MarstrandBoris ModrauLars NeebNatalia Perez de la OssaJosep PuigPeter RinglebPascal RoyEnno ScheelWouter SchonewilleJoaquin SerenaStefan SunaertKersten VillringerAnke WoutersVincent ThijsMartin EbingerMatthias EndresJochen B FiebachRobin LemmensKeith W MuirNorbert NighoghossianSalvador PedrazaChristian Gerloffnull nullPublished in: The New England journal of medicine (2018)
In patients with acute stroke with an unknown time of onset, intravenous alteplase guided by a mismatch between diffusion-weighted imaging and FLAIR in the region of ischemia resulted in a significantly better functional outcome and numerically more intracranial hemorrhages than placebo at 90 days. (Funded by the European Union Seventh Framework Program; WAKE-UP ClinicalTrials.gov number, NCT01525290; and EudraCT number, 2011-005906-32 .).