A novel DNA damage response signature of IDH-mutant grade II and grade III astrocytoma at transcriptional level.

Qi LiuKuanyu WangRuoyu HuangXuezhi TongTao JiangJiangfei WangPei Yang

Published in: Journal of cancer research and clinical oncology (2020)

We developed a two-gene signature which can effectively predict the prognosis of patients with IDH-mutant grade II and grade III astrocytoma. It suggests a novel classification of astrocytoma with better prognostic accuracy based on the expression of DNA damage response genes.

Keyphrases

dna damage response
wild type
dna repair
genome wide
low grade
machine learning
poor prognosis
gene expression
deep learning
genome wide identification
dna methylation
dna damage
copy number
oxidative stress
bioinformatics analysis