Preliminary Study of the Impact of Single-Nucleotide Polymorphisms of IL-1α, IL-1β and TNF-α Genes on the Occurrence, Severity and Treatment Effectiveness of the Major Depressive Disorder.
Katarzyna BialekPiotr CzarnyCezary WatalaEwelina SynowiecPaulina WignerMichal BijakMonika TalarowskaPiotr GaleckiJanusz SzemrajTomasz SliwińskiPublished in: Cellular and molecular neurobiology (2020)
The purpose of the preliminary study was to determine whether the occurrence of certain SNPs of genes encoding IL-1α, IL-1β, and TNF-α is associated with the development of depression. Five polymorphisms were selected: i.e. c.-1560G > C-IL-1β (rs1143623), c. -118 C > T-IL-1β (rs1143627), c.340G > T-IL-1α (rs17561), c.-1211T > C-TNF-α (rs1799964) and c.-488G > A-TNF-α (rs1800629). These were analyzed using TaqMan probes. The genotypes of the analyzed polymorphisms were found to be associated with disease severity and may affect the effectiveness of antidepressant therapy. In addition, the gene-gene analysis confirmed that combined genotypes of investigated SNPs may modulate the risk of depression.
Keyphrases
- major depressive disorder
- genome wide
- rheumatoid arthritis
- randomized controlled trial
- systematic review
- bipolar disorder
- depressive symptoms
- genome wide identification
- copy number
- small molecule
- physical activity
- bone marrow
- mesenchymal stem cells
- high resolution
- fluorescence imaging
- data analysis
- bioinformatics analysis