Laminar analysis of the cortical T1/T2-weighted ratio at 7T.
Maria PetraccaMohamed Mounir El MendiliMatteo MoroSirio CocozzaKornelius PodranskiLazar FleysherMatilde InglesePublished in: Neurology(R) neuroimmunology & neuroinflammation (2020)
Laminar analysis of T1w/T2w ratio mapping confirms the presence of cortical damage in MS and shows a variable expression of intracortical damage according to the disease phenotype. Although in the relapsing-remitting stage, only the subpial layer appears susceptible to damage, in progressive patients, widespread cortical abnormalities can be observed, not only, as described before, with regard to myelin/iron concentration but, possibly, to other microstructural features.
Keyphrases
- multiple sclerosis
- white matter
- oxidative stress
- end stage renal disease
- ejection fraction
- newly diagnosed
- poor prognosis
- chronic kidney disease
- mass spectrometry
- prognostic factors
- magnetic resonance
- peritoneal dialysis
- magnetic resonance imaging
- computed tomography
- systemic lupus erythematosus
- patient reported outcomes
- patient reported
- network analysis