Inhibition of the Phosphatidylinositol-3 Kinase Pathway Using Bimiralisib in Loss-of-Function NOTCH1-Mutant Head and Neck Cancer.
Faye M JohnsonFilip JankuMohamed A GoudaHai T TranJitesh D KawediaDebora SchmitzHendrik StreefkerkJ Jack LeeClark R AndersenDefeng DengSeema RawalPooja A ShahAdel K El-NaggarJason M JohnsonMitchell J FrederickPublished in: The oncologist (2022)
Although the trial was small, outcomes with bimiralisib were better than the historical standard of care; Results will need to be confirmed in a larger trial. The lack of cl-NOTCH1 was consistent with loss-of-function mutations and validated our mutation function algorithm. The ability to detect NOTCH1 mutations in blood will help future studies. (ClinicalTrials.gov Identifier: NCT03740100).