Discordant effects of Janus kinases inhibition ex-vivo on inflammatory responses in colonic compared to ileal mucosa.

Kawsar KaboubHanan Abu-TahaJessica ArrouasseEfrat Shaham-BardaNir WasserbergLucille Hayman-ManzurAdi FriedenbergAdva Levy-BardaIdan GorenZohar LeviHagar Banai-EranIrit Avni-BironJacob E OllechTali Sharar-FischlerHenit YanaiSarit Cohen-KedarIris DotanKeren M Rabinowitz

Published in: Journal of Crohn's & colitis (2024)

Site-specific anti-inflammatory effect of JAK inhibition by tofacitinib was noticed, whereby the colon was more robustly affected than the ileum. Ex-vivo response to tofacitinib is individual. JAK inhibition may attenuate inflammation by decreasing iNOS expression. Ex-vivo mucosal platforms may be a valuable resource for studying personalized drug effects in patients with IBD.

Keyphrases

ulcerative colitis
rheumatoid arthritis
anti inflammatory
poor prognosis
oxidative stress
binding protein
nitric oxide synthase