Taken together, these results suggested that shikonin might affect the expression of GADD45B and PPP3CC through the JNK/P38/MAPK pathway, therefore exerting an inhibitory effect on the proliferation and migration of cancer cells. To our knowledge, this is the first study reporting the role of shikonin in upregulating TSGs to activate the JNK/P38/MAPK signaling pathways in NSCLC.
Keyphrases
- signaling pathway
- induced apoptosis
- small cell lung cancer
- pi k akt
- cell death
- epithelial mesenchymal transition
- advanced non small cell lung cancer
- poor prognosis
- single cell
- healthcare
- endoplasmic reticulum stress
- brain metastases
- oxidative stress
- cell therapy
- stem cells
- epidermal growth factor receptor
- bone marrow