Identification of novel key lncRNAs involved in periodontitis by weighted gene co-expression network analysis.

Su-Han Jin Rui-Hao ZhouXiao-Yan GuanJian-Guo ZhouJian-Guo Liu

Published in: Journal of periodontal research (2019)

In our study, we found that 3 hub DElncRNAs (LINC00687, LBX2-AS1 and LINC01566) may be involved in the pathogenesis of periodontitis based on WGCNA and Limma analysis. Our study aimed to elucidate the mechanisms involved in periodontitis at the genetic and epigenetic levels by constructing a ceRNA network associated with lncRNA. Besides, identification DEGs of differential LBX2-AS1 and functional annotation showed that LBX2-AS1 might be associated with periodontitis.

Keyphrases

network analysis
long non coding rna
poor prognosis
cell proliferation
long noncoding rna
gene expression
genome wide
dna methylation
magnetic resonance
copy number
magnetic resonance imaging
computed tomography
contrast enhanced