Targeting CXCR4 impaired T regulatory function through PTEN in renal cancer patients.

Sara SantagataGiuseppina ReaAnna Maria BelloAnna CapiluongoMaria NapolitanoSonia DesicatoAlessandra FragaleCrescenzo D'AlterioAnna Maria TrottaCaterina IeranòLuigi PortellaFrancesco PersicoMarilena Di NapoliSalvatore Di MaroFlorinda FeroceRosa AzzaroLucia GabrieleNicola LongoSandro PignataSisto PerdonàStefania Scala

Published in: British journal of cancer (2024)

R54 impairs Tregs function in primary RCC patients targeting PTEN/PI3K/AKT pathway, reducing TSDR demethylation and FOXP3 and DNMT1 expression. Thus, CXCR4 targeting is a strategy to inhibit Tregs activity in the RCC tumour microenvironment.

Keyphrases

end stage renal disease
cancer therapy
cell proliferation
ejection fraction
chronic kidney disease
renal cell carcinoma
poor prognosis
regulatory t cells
stem cells
pi k akt
dna methylation
peritoneal dialysis
transcription factor
gene expression
patient reported outcomes
immune response
dendritic cells