Previous studies have revealed a positive relationship between self-esteem and prosocial behavior. Based on social mentality theory, the authors propose that self-compassion as a self-soothing system moderates the relationship in adolescents girls and not in adolescent boys. A total of 540 adolescents from 12 to 14 years old completed the Rosenberg Self-Esteem Scale, Self-Compassion Scale, and Prosocial Tendencies Measure. The results showed that both self-esteem and self-compassion were positively correlated with prosocial behavior, self-compassion moderated the relationship between self-esteem and altruistic or anonymous prosocial behavior, and self-compassion moderated the relationship between self-esteem and dire prosocial behavior and the moderating effect was moderated by gender. In conclusion, the present study indicates that self-esteem and self-compassion, as two important aspects of the self, are beneficial to prosocial behavior in adolescence. Self-compassion strengthens the relationship between self-esteem and specific prosocial behavior, especially for adolescent girls.