Clinical and Nonclinical Disposition and In Vitro Drug-Drug Interaction Potential of Felcisetrag, a Highly Selective and Potent 5-HT 4 Receptor Agonist.

Sandeepraj PusalkarSwapan K ChowdhuryRichard CzerniakXiaochun ZhuYuexian LiSuresh K BalaniDiane Ramsden

Published in: European journal of drug metabolism and pharmacokinetics (2022)

Felcisetrag is primarily cleared in humans through renal excretion. Although the metabolism of felcisetrag is primarily through CYP3A, the potential for clinically relevant DDI as a victim is significantly reduced as metabolism plays a minor role in the overall clearance.

Keyphrases

human health
adverse drug
drug induced
risk assessment
climate change