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ACPA IgG galactosylation associates with disease activity in pregnant patients with rheumatoid arthritis.

Albert BondtLise HafkenscheidDavid FalckT Martijn KuijperYoann RomboutsJohanna M W HazesManfred WuhrerRadboud J E M Dolhain
Published in: Annals of the rheumatic diseases (2018)
In ACPA-positive RA, the pregnancy-induced change in galactosylation of ACPA-IgG, and not that of total IgG, associates with changes in disease activity. These data may indicate that in ACPA-positive patients the galactosylation of ACPA-IgG is of more pathogenic relevance than that of total IgG.
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