ACPA IgG galactosylation associates with disease activity in pregnant patients with rheumatoid arthritis.
Albert BondtLise HafkenscheidDavid FalckT Martijn KuijperYoann RomboutsJohanna M W HazesManfred WuhrerRadboud J E M DolhainPublished in: Annals of the rheumatic diseases (2018)
In ACPA-positive RA, the pregnancy-induced change in galactosylation of ACPA-IgG, and not that of total IgG, associates with changes in disease activity. These data may indicate that in ACPA-positive patients the galactosylation of ACPA-IgG is of more pathogenic relevance than that of total IgG.
Keyphrases
- disease activity
- rheumatoid arthritis
- systemic lupus erythematosus
- rheumatoid arthritis patients
- ankylosing spondylitis
- juvenile idiopathic arthritis
- end stage renal disease
- newly diagnosed
- chronic kidney disease
- ejection fraction
- prognostic factors
- preterm birth
- oxidative stress
- diabetic rats
- electronic health record
- big data
- deep learning
- pregnancy outcomes
- artificial intelligence