Relationship between hepatic and systemic angiopoietin-like 3, hepatic Vitamin D receptor expression and NAFLD in obesity.
Ilaria BarchettaFlavia A CiminiCaterina ChiappettaLaura BertocciniValentina CeccarelliDanila CapocciaMelania GagginiClaudio Di CristofanoCarlo Della RoccaGianfranco SilecchiaFrida LeonettiAndrea LenziFrancesco RubinoMaria Gisella CavalloPublished in: Liver international : official journal of the International Association for the Study of the Liver (2020)
Hepatic ANGPTL3 expression correlates with greater VDR expression, presence and severity of NAFLD and translates in increased circulating ANGPTL3, likely as a result of its modulation by up-regulated hepatic VDR in NAFLD. This study provides novel insights to potential mechanisms underlying ANGPTLs-mediated ectopic fat accumulation and NAFLD development in obesity.