Water-Mediated on-Demand Detachable Solid-State Adhesive of Porous Hydroxyapatite for Internal Organ Retractions.

Novel adhesives for biological tissues offer an advanced surgical approach. Here, we report the development and application of solid-state adhesives consisting of porous hydroxyapatite (HAp) biocompatible ceramics as novel internal organ retractors. The operational principles of the porous solid-state adhesives were experimentally established in terms of water migration from biological soft tissues into the pores of the adhesives, and their performance was evaluated on several soft tissues with different hydration states. As an example of practical medical utility, HAp adhesive devices demonstrated the holding ability of porcine livers and on-demand detachability in vivo, showing great potential as internal organ retractors in laparoscopic surgery. This article is protected by copyright. All rights reserved.