The PI3K/Akt pathway plays a critical role in the progression and treatment of oral squamous cell carcinoma (OSCC). Recent research has uncovered the involvement of long non-coding RNAs (lncRNAs) in regulating this pathway, influencing OSCC cell proliferation, survival, and metastasis. This review explores the latest findings on how certain lncRNAs act as either cancer promoters or cancer inhibitors within the PI3K/Akt signaling pathway. Certain lncRNAs act as oncogenic or tumor-suppressive agents, making them potential diagnostic and prognostic markers. Targeting these lncRNAs may lead to novel therapeutic strategies. The evolving fields of precision medicine and artificial intelligence promise advancements in OSCC diagnosis and treatment, enabling more personalized and effective patient care.
Keyphrases
- long non coding rna
- artificial intelligence
- poor prognosis
- papillary thyroid
- big data
- cell proliferation
- signaling pathway
- network analysis
- machine learning
- squamous cell
- genome wide analysis
- genome wide identification
- deep learning
- pi k akt
- transcription factor
- cell cycle
- lymph node metastasis
- childhood cancer
- human health
- free survival
- endoplasmic reticulum stress