Nationwide epidemiology of early-onset sepsis in Israel 2010-2015, time to re-evaluate empiric treatment.

Daniel GlikmanNitzan CurielAharona Glatman-FreedmanOrli MeggedIlan YoungsterRonella MaromKaren LavieTatiana SmolkinMara TroitzkyMichal Steinnull null

Published in: Acta paediatrica (Oslo, Norway : 1992) (2019)

In this nationwide study, EOS was caused predominantly by Gram-negatives, with high gentamicin resistance and ESBL phenotype rates, without identifiable resistance risk factors. As EOS is life-threatening, modification of empiric therapy for amikacin-based regimens should be considered, mainly in preterms.

Keyphrases

early onset
risk factors
late onset
escherichia coli
intensive care unit
urinary tract infection
gram negative
cross sectional
klebsiella pneumoniae
multidrug resistant