Proteomics of Sentinel Lymph Nodes in Early Breast Cancer for Identification of Thymidylate Synthase as a Potential Biomarker to Flag Metastasis: A Preliminary Study.
Sheetal PathaniaMohd Imran KhanAbhishek KumarAshish Kumar GuptaKomal RaniTanvi Ramesh ParasharJnaneshwari JayaramPiyush RanjanAnurag SrivastavaSandeep MathurSmriti HariGururao HariprasadPublished in: Cancer management and research (2020)
Differential in gel expression proteomics is an ideal platform for the identification of potential protein biomarker candidates that can differentiate metastatic from non-metastatic lymph nodes in early breast cancer. The identification of thymidylate synthase offers a scope to develop an on-table diagnostic kit to assess the status of sentinel lymph nodes during mastectomy procedure to guide surgical management of axillary lymph nodes in early breast cancer.
Keyphrases
- lymph node
- early breast cancer
- sentinel lymph node
- neoadjuvant chemotherapy
- small cell lung cancer
- squamous cell carcinoma
- mass spectrometry
- bioinformatics analysis
- poor prognosis
- binding protein
- high throughput
- minimally invasive
- label free
- early stage
- human health
- climate change
- small molecule
- long non coding rna
- amino acid
- rectal cancer